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Dentagen

Periodontal disease consists of cycles of active destruction (periodontitis) and dormancy leading to progressive breakdown of tooth attachment.

Preventing plaque formation stops the progression of periodontal disease.

Dentagen – Discovery of a novel solution for dental plaque control

Hundreds of plant extracts and plant fractions were tested for their inhibitory potential on plaque formation.

The natural anti-plaque compound was elucidated and coded RF2.

All products in the Dentagen range contain the active principle RF2.

Dentagen – Controlling biofilm

Traditional methods of dental plaque control have relied upon mechanical or bactericidal actions to destroy the normal mouth flora. However, biofilm formation begins immediately after this treatment. So unless performed regularly significant plaque reformation will occur.

Dentagen provides a different approach to dental plaque control. By affecting bacterial membrane fluidity, planktonic cells are able to exist but without the ability to form biofilm1. Even at very low concentrations, plaque inhibition is continuous. RF2 is not bactericidal and allows the natural and healthy mouth and gut flora to exist without promoting dental disease.

 

Dentagen – Thoroughly tested

Picture of the dental plaque mimicking biofilm flow system (Modified Robbins Device). Notice the clean surface (left) in the RF2-treated device versus the plaque-covered surface (right) in the control device.

The active principle RF2 has been thoroughly and rigorously tested with in vitro studies2 and clinical tests.

In a randomised, blinded trial RF2 was shown to have excellent inhibition of biofilm. Even when accounting for the mechanical action of application (-11%), RF2 showed statistically significant results (-47%).

The trial was conducted to Veterinary Oral Health Council standards measuring Whole Mouth Mean (WMM) scores.



Genitrix Ltd      Genitrix House      Daux Road      Billingshurst      West Sussex      RH14 9SJ
t: +44 (0) 1403 786345      f: +44 (0) 1403 786346      e: mail@genitrix.co.uk